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Multiple Choice

During involution of the breast, what tissue change occurs?

During involution, the breast regresses from its lactating state. The glandular and ductal/lobular (fibroglandular) tissue diminishes, and the spaces they occupied are filled by adipose (fat) tissue. So the tissue change is glandular tissue being replaced by fat. This shift toward more fat makes the breast softer and less dense on imaging. It’s not a reversal where fat becomes glandular tissue, nor does muscle or cartilage replace glandular elements.

During involution, the breast regresses from its lactating state. The glandular and ductal/lobular (fibroglandular) tissue diminishes, and the spaces they occupied are filled by adipose (fat) tissue. So the tissue change is glandular tissue being replaced by fat. This shift toward more fat makes the breast softer and less dense on imaging. It’s not a reversal where fat becomes glandular tissue, nor does muscle or cartilage replace glandular elements.